| Home Team | Home Pitcher | Visiting Team | Visiting Pitcher | Date/Time | Notes |
|---|---|---|---|---|---|
| Spartanburg | Woodmont | 04/26 06:30 PM | |||
| Summerville | Fort Dorchester | 04/26 07:00 PM | |||
| James Island Trojans | West Ashley Wildcats | 04/26 06:30 PM | |||
| Dutch Fork | Lexington | 04/26 06:30 PM | |||
| West-Oak | Liberty | 04/26 06:30 PM | |||
| Airport | Cardinal Newman | 04/26 07:00 PM | |||
| Hillcrest | TL Hanna | 04/26 06:30 PM | |||
| Wando | Lucy Beckham | 04/26 06:00 PM | |||
| Greenville | Wren | 04/26 07:00 PM | |||
| Stratford | Carolina Forest (10-12) | Nolan Alexander (4-2) | 04/30 06:30 PM | ||
| Laurens | Northwestern | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| Greenwood | Midland Valley | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| North Augusta | Greenville | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| Catawba Ridge | Eastside | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| Airport | Westside | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| Riverside | Indian Land | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| Easley | Aiken | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| Greer | Lancaster | 04/29 12:00 AM | 4A Upper State Playoffs | ||
| North Myrtle Beach | At Large | 04/29 12:00 AM | 4A Lower State Playoffs | ||
| Lucy Beckham | Irmo | 04/29 12:00 AM | 4A Lower State Playoffs | ||
| May River | Myrtle Beach | 04/29 12:00 AM | 4A Lower State Playoffs | ||
| AC Flota | At Large | 04/29 12:00 AM | 4A Lower State Playoffs | ||
| James Island | At Large | 04/29 12:00 AM | 4A Lower State Playoffs | ||
| Hartsville | Westwood | 04/29 12:00 AM | 4A Lower State Playoffs | ||
| Lugoff-Elgin | At Large | 04/29 12:00 AM | 4A Lower State Playoffs | ||
| West Florence | Hilton Head | 04/29 12:00 AM | 4A Lower State Playoffs | ||
| Easley | Aiken | 04/29 12:00 AM | |||
| Greer | Lancaster | 04/29 12:00 AM | |||
| North Myrtle Beach | At-Large | 04/29 12:00 AM | |||
| Crescent | Broome | 04/30 12:00 AM | 3A Upper State Playoffs | ||
| Lucy Beckham/May River | Irmo | 04/29 12:00 AM | |||
| AC Flora/Lugoff-Elgin | At-Large | 04/29 12:00 AM | |||
| Region 4 #2 | Fountain Inn | 04/30 12:00 AM | 3A Upper State Playoffs | ||
| James Island | At-Large | 04/29 12:00 AM | |||
| Hartsville | RNE/Westwood | 04/29 12:00 AM | |||
| Wren | Region 4 #1 | 04/30 12:00 AM | 3A Upper State Playoffs | ||
| Daniel | Travelers Rest | 04/30 12:00 AM | 3A Upper State Playoffs | ||
| Lugoff-Elgin | At-Large | 04/29 12:00 AM | |||
| Blue Ridge | Pendleton | 04/30 12:00 AM | 3A Upper State Playoffs | ||
| West Florence | Hilton Head | 04/29 12:00 AM | |||
| Emerald | Powdersville | 04/30 12:00 AM | 3A Upper State Playoffs | ||
| Chapman | Seneca | 04/30 12:00 AM | 3A Upper State Playoffs | ||
| Gilbert | Lake City | 04/30 12:00 AM | 3A Lower State Playoffs | ||
| Region 8 #2 | Georgetown | 04/30 12:00 AM | 3A Lower State Playoffs | ||
| Camden | Orangeburg-Wilkinson | 04/30 12:00 AM | 3A Lower State Playoffs | ||
| Loris | Region 8 #3 | 04/30 12:00 AM | 3A Lower State Playoffs |
