| Home Team | Home Pitcher | Visiting Team | Visiting Pitcher | Date/Time | Notes |
|---|---|---|---|---|---|
| Woodmont | Daniel | 04/24 06:30 PM | |||
| Spartanburg | Woodmont | 04/26 06:30 PM | |||
| Fort Dorchester | Summerville | 04/24 07:00 PM | |||
| Summerville | Fort Dorchester | 04/26 07:00 PM | |||
| Blue Ridge | Westside | 04/24 06:00 PM | |||
| Carolina Forest | Nolan Alexander | Waccamaw | Diego Patrick | 04/23 06:30 PM | |
| Waccamaw | Johnsonville | 04/25 06:30 PM | |||
| Carolina Forest | Brett Barker | Liverpool (NY) | 04/24 06:00 PM | @ Ripken Experience | |
| Carolina Forest | Watertown (NY) | 04/25 06:00 PM | @Ripken Experience | ||
| West Ashley Wildcats | Wando Warriors | 04/23 07:00 PM | |||
| James Island Trojans | West Ashley Wildcats | 04/26 06:30 PM | |||
| Palmetto | Southside | 04/23 06:00 PM | DH @ Palmetto | ||
| Liberty | Palmetto | 04/24 06:30 PM | |||
| Lexington | Dutch Fork | Boone Miller | 04/24 06:30 PM | ||
| Dutch Fork | Lexington | 04/26 06:30 PM | |||
| Liberty | Palmetto | 04/24 06:30 PM | |||
| West-Oak | Liberty | 04/26 06:30 PM | |||
| Airport | Gilbert | 04/23 07:00 PM | |||
| Gilbert | Airport | 04/24 07:00 PM | |||
| Airport | Cardinal Newman | 04/26 07:00 PM | |||
| Berkeley | Cane Bay | 04/25 06:30 PM | Region 6-AAAAA | ||
| Cane Bay | Berkeley | 04/24 07:00 PM | Region 6-AAAAA | ||
| TL Hanna | Hillcrest | 04/24 06:30 PM | |||
| Hillcrest | TL Hanna | 04/26 06:30 PM | |||
| Gray Collegiate | Legion | 04/25 07:00 PM | Senior Night | ||
| Hilton Head | Lucy Beckham | 04/24 06:30 PM | Region 7-AAAA | ||
| May River | Lucy Beckham | 04/25 06:30 PM | Region 7-AAAA | ||
| Wando | Lucy Beckham | 04/26 06:00 PM | |||
| Cardinal Newman | Gray Collegiate | 04/23 07:00 PM | |||
| Batesburg Leesville | Aiken | 04/23 06:00 PM | |||
| Aiken | Batesburg Leesville | 04/25 06:00 PM | |||
| Sumter | Socastee | 04/24 06:00 PM | Region 5 makeup game | ||
| Wren | Fountain Inn | 04/23 06:30 PM | |||
| Fountain Inn | Wren | 04/25 06:30 PM | |||
| Greenville | Wren | 04/26 07:00 PM | |||
| Dillon | Loris | 04/23 06:30 PM | Region game-makeup | ||
| Daniel | Ian McCrary | Crescent | 04/23 06:30 PM | @ Westside - Region 1-3A Championship Game |
